Reaktion #640531

Reaktionsgleichung

4-[1-(4-chloro-3-nitrophenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine

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title compound

4-[1-(3-Amino-4-chlorophenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine

Lösungsmittel

ethanol

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationFiltration and evaporation at reduced pressure
2. 2
   Sonstigegives the crude product
3. 3
   SonstigePurification
4. 4
   Extraktionby extraction with ethyl acetate and chromatography on silicagel

Vorschrift

To a stirred solution of 4-[1-(4-chloro-3-nitrophenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine (0.07 g, 0.175 mmol) in ethanol (6 ml) and water (1 ml) is added two drops of concentrated hydrochloric acid and iron powder (0.1 g, 17.5 mmol). The reaction mixture is heated at 80° C. for 8 hours. Filtration and evaporation at reduced pressure gives the crude product. Purification by extraction with ethyl acetate and chromatography on silicagel yields the title compound as colorless solid, m.p. 228-230° C.

Quelle