Reaktion #640522

Reaktionsgleichung

4-(1H-benzimidazol-2-yl)-furazan-3-ylamine

potassium carbonate

iodomethoxy benzene

→

title compound

4-(1-Phenoxymethyl-1H-benzimidazol-2-yl)-furazan-3-ylamine

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeEvaporation of the solvent under reduced pressure
2. 2
   Sonstigepartitioning of the resulting residue between water and ethyl acetate
3. 3
   Trocknenby drying of the organic solution over sodium sulphate and chromatography of the residue

Vorschrift

To a solution of 4-(1H-benzimidazol-2-yl)-furazan-3-ylamine (0.10 g, 0.497 mmol) is added potassium carbonate (0.172 g, 1.24 mmol) and iodomethoxy benzene (0.128 g, 0.546 mmol). The mixture is stirred over night. Evaporation of the solvent under reduced pressure and partitioning of the resulting residue between water and ethyl acetate followed by drying of the organic solution over sodium sulphate and chromatography of the residue gives the title compound as a colorless solid, m.p. 171-173° C.

Quelle