Reaktion #63995

Reaktionsgleichung

hydrochloric acid

potassium acid phosphate

dimethyl 3-methylglutarate

potassium carbonate

→

desired product

3-(R)-methylglutaric acid mono methyl ester

Lösungsmittel

CH3OH

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigefour necked flask fitted with
2. 2
   workup.ADDITIONwas added 2.5 1
3. 3
   Extraktionthe product extracted with diethyl ether
4. 4
   Trocknendried over magnesium sulfate
5. 5
   Einengenconcentrated in vacuo
6. 6
   Sonstigeto give 114 g

Vorschrift

To a 5 1. four necked flask fitted with a stirred and pH electrode was added 2.5 1. of 0.1M potassium acid phosphate buffer pH 7.0 followed by 150 mg. of pig liver esterase and 150 g. of dimethyl 3-methylglutarate. The pH of the mixture was maintained at about 6.85 by periodic addition of a 10% potassium carbonate solution. After 2.5 hours the reaction was acidified with 10% hydrochloric acid to pH 2.0 and the product extracted with diethyl ether. The extracts were combined, dried over magnesium sulfate and concentrated in vacuo to give 114 g. of the desired product, [alpha]D =-1.48 (CH3OH C=0.086 g/ml).

Quelle