Reaktion #63979

Reaktionsgleichung

hydrochloric acid

1-(3,4-dichlorophenyl)-1-cyclobutanecarbonitrile

propyl magnesium bromide

ether

propyl bromide

magnesium

ether

ether

→

1-butyryl-1-(3,4-dichlorophenyl)cyclobutane

Lösungsmittel

toluene

Water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture heated
2. 2
   Temperaturunder reflux for one hour
3. 3
   Temperaturthe mixture heated
4. 4
   Temperaturunder reflux for one hour
5. 5
   ExtraktionThe reaction mixture was extracted with ether
6. 6
   Waschenafter washing
7. 7
   Sonstigedrying the extract

Vorschrift

A solution of 1-(3,4-dichlorophenyl)-1-cyclobutanecarbonitrile prepared as described in Example 1 (35.2 g) in ether (100 ml) was added to a solution of propyl magnesium bromide prepared by the reaction of propyl bromide (32 g) with magnesium turnings (6.36 g) in ether (100 ml). The ether was replaced by dry toluene and the mixture heated under reflux for one hour. Water (200 ml) and then concentrated hydrochloric acid (120 ml) were added and the mixture heated under reflux for one hour. The reaction mixture was extracted with ether and after washing and drying the extract yielded a residue from which 1-butyryl-1-(3,4-dichlorophenyl)cyclobutane (b.p. 120°-128° C. at 0.25 mm) was distilled.

Quelle