Reaktion #63975

Reaktionsgleichung

formamide

N-formyl-1-[1-(3,4-dichlorophenyl)cyclobutyl]ethylamine

→

hydrochloric acid

1-[1-(3,4-dichlorophenyl)cyclobutyl]ethylamine

Lösungsmittel

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe product isolated
2. 2
   Temperaturby cooling the reaction mixture
3. 3
   Sonstigecollecting the solid
4. 4
   Sonstigeproduced by filtration

Vorschrift

The preparation of N-formyl-1-[1-(3,4-dichlorophenyl)cyclobutyl]ethylamine (m.p. 124°-125° C.) (Example 1(a) Formula I R1 =Me; R2 =H; R3 =H; R4 =CHO; R5 =4--Cl and R6 =3--Cl) described above was repeated and the product isolated by cooling the reaction mixture and collecting the solid produced by filtration. The formamide was then hydrolysed by concentrated hydrochloric acid in industrial methylated spirit to give the hydrochloride salt of 1-[1-(3,4-dichlorophenyl)cyclobutyl]ethylamine.

Quelle