Reaktion #63959

Reaktionsgleichung

Chloroform

3-dimethylaminomethylene-6-nitro-4-oxo-1-propionyl-1,2,3,4-tetrahydroquinoline

hydrazine hydrate

acetic acid

acetic acid

→

4,5-dihydro-8-nitro-5-propionyl-1H-pyrazolo[4,3-c]quinoline

Ausbeute 93.0%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeevaporated in vacuo
2. 2
   WaschenThe residual solid was washed with water
3. 3
   Sonstigedried
4. 4
   Sonstigerecrystallized from a mixture of chloroform and methanol

Vorschrift

Chloroform (50 ml) was added to a mixture of 3-dimethylaminomethylene-6-nitro-4-oxo-1-propionyl-1,2,3,4-tetrahydroquinoline (3.03 g), hydrazine hydrate (0.6 g), and acetic acid (0.78 g) in methanol (50 ml) and stirred at room temperature for 8 hours. To the mixture was added acetic acid (2 ml) and evaporated in vacuo. The residual solid was washed with water, dried, and recrystallized from a mixture of chloroform and methanol to give 4,5-dihydro-8-nitro-5-propionyl-1H-pyrazolo[4,3-c]quinoline (2.53 g).

Quelle