Reaktion #63882

Reaktionsgleichung

isothiourea

2-(3-piperidinomethylbenzyl)isothiourea dihydrochloride

3-chloropropionitrile

sodium hydroxide

→

3-(3-piperidinomethylbenzylthio)propionitrile

Lösungsmittel

water

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   ExtraktionThe reaction mixture was extracted with ethyl acetate
2. 2
   Waschenthe extracts washed with water
3. 3
   Sonstigedried
4. 4
   Sonstigeevaporated

Vorschrift

A stirred solution of the above isothiourea (1.2 g) and 3-chloropropionitrile (0.4 ml) in a mixture of water (7 ml) and ethanol (5 ml) was treated at 0°-5° C. with 2.5N sodium hydroxide (5.3 ml). The reaction mixture was stirred at 0°-5° C. for a further hour and then allowed to warm to 20° C. The reaction mixture was extracted with ethyl acetate and the extracts washed with water, dried and evaporated to provide 3-(3-piperidinomethylbenzylthio)propionitrile as an oil.

Quelle