Reaktion #63871

Reaktionsgleichung

N-(3-Hydroxybenzyl)piperidine

6-bromohexanenitrile

potassium carbonate

→

6-(3-piperidinomethylphenoxy)hexanenitrile

Lösungsmittel

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture was cooled
2. 2
   Filtrationfiltered
3. 3
   SonstigeThe solvent was removed by evaporation
4. 4
   Temperaturthe residue was heated
5. 5
   Sonstigeto remove unreacted 6-bromohexanenitrile

Vorschrift

N-(3-Hydroxybenzyl)piperidine (9.55 g) was heated with 6-bromohexanenitrile (10.2 g) and potassium carbonate (13.8 g) under reflux in acetone (150 ml) for 66 hours. The reaction mixture was cooled and filtered. The solvent was removed by evaporation and the residue was heated with stirring at 100° C. for one hour to remove unreacted 6-bromohexanenitrile and to yield 6-(3-piperidinomethylphenoxy)hexanenitrile as an oil.

Quelle