Reaktion #63798

Reaktionsgleichung

1-bromo-2-(4-nitrophenyl)-2-ethanone

2-amino-5-methylpyridine

sodium bicarbonate

→

6-Methyl-2-(4-nitrophenyl)imidazo[1,2-a]pyridine

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturrefluxing
2. 2
   Temperaturare maintained for 3 hours
3. 3
   Temperaturthe reaction mixture is then cooled
4. 4
   Sonstigethe ethanol evaporated off under reduced pressure
5. 5
   workup.STIRRINGThe evaporation residue is stirred in 700 ml of water at 70° C. for 3 hours
6. 6
   Filtrationthe insoluble material is then filtered off
7. 7
   Waschenwashed with 50 ml of ethanol
8. 8
   Trocknenether and dried

Vorschrift

59.5 g (0.2 mole) of 1-bromo-2-(4-nitrophenyl)-2-ethanone, 21.6 g (0.2 mole) of 2-amino-5-methylpyridine and 34 g of sodium bicarbonate are reacted in 200 ml of 95% strength ethanol. Stirring and refluxing are maintained for 3 hours, and the reaction mixture is then cooled and the ethanol evaporated off under reduced pressure. The evaporation residue is stirred in 700 ml of water at 70° C. for 3 hours, and the insoluble material is then filtered off, washed with 50 ml of ethanol and then ether and dried. M.p. 237°-239° C.

Quelle