Reaktion #637910
ord-95bb1aaa2a244ad495abb34ffc7d2d28
Reaktionsgleichung
3-(2,4-Dimethoxy-benzyloxy)-1H-benzo[4,5]thieno[3,2-d]pyrimidine-2,4-dione
methyl 5-chloromethyl-2-furoate
→
title compound
5-(3-Hydroxy-2,4-dioxo-3,4-dihydro-2H-benzo[4,5]thieno[3,2-d]pyrimidin-1-ylmethyl)-furan-2-carboxylic acid methyl ester
Edukte
Reagenzien
Keine
Reaktionsbedingungen
Detaillierte Bedingungen
See reaction.notes.procedure_details.
Vorschrift
Following general procedure B2 and D1, 3-(2,4-Dimethoxy-benzyloxy)-1H-benzo[4,5]thieno[3,2-d]pyrimidine-2,4-dione was alkylated with methyl 5-chloromethyl-2-furoate and subsequently deprotected to provide the title compound as a white solid. 1H NMR (d6-DMSO, 300 MHz) δ 3.64 (s, 3H); 5.60 (s, 2H); 6.48 (d, J=3 Hz, 1H); 7.09 (d, J=3 Hz, 1H); 7.32 (dd, J=8 Hz, 1H); 7.44 (dd, J=8 Hz, 1H); 7.92 (d, J=9 Hz, 1H); 8.00 (d, J=8 Hz, 1H); Ret. time=2.33 min., m/z=373.0.