Reaktion #6376

Reaktionsgleichung

2,4-dihydroxy-phenyl-(3',4'-dimethoxy-benzyl)-ketone

ethyl-orthoformate

morpholine

→

7-hydroxy-3',4'-dimethoxy-isoflavone

Lösungsmittel

dimethyl-formamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture is maintained at 80°-85° C.
2. 2
   Sonstigein the second hour a solid precipitates
3. 3
   workup.ADDITIONAfter 6 hours 1OO ml of chloroform are added to the mixture
4. 4
   Filtrationthe precipitated substance is filtered
5. 5
   Sonstigedried

Vorschrift

14.4 g (0.05 mole) of 2,4-dihydroxy-phenyl-(3',4'-dimethoxy-benzyl)-ketone are reacted with 10.5 g (0.07 mole) ethyl-orthoformate in 10 ml of dimethyl-formamide in the presence of 1 ml morpholine. The reaction mixture is maintained at 80°-85° C., and in the second hour a solid precipitates. After 6 hours 1OO ml of chloroform are added to the mixture, the precipitated substance is filtered and dried. 7-hydroxy-3',4'-dimethoxy-isoflavone is obtained.

Quelle