Reaktion #6375

Reaktionsgleichung

2,4-dihydroxy-phenyl-benzyl-ketone

dimethyl-formamide

morpholine

ethyl-orthoformate

→

7-hydroxy-isoflavone

Ausbeute 90.5%

Lösungsmittel

chloroform

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling the crystalline substance
2. 2
   Filtrationfiltered
3. 3
   Sonstigedried

Vorschrift

A mixture of 100 kg (438.5 mole) of 2,4-dihydroxy-phenyl-benzyl-ketone, 38 kg of dimethyl-formamide, 5.2 kg of morpholine and 75 kg (506 mole) of ethyl-orthoformate is stirred at 80°-90° C., while within one hour crystallization is initiated. 360 kg of chloroform are added to the suspension after 7 hours at 60° C. After cooling the crystalline substance is centrifuged, covered with chloroform, filtered and dried. 94.5 kg of 7-hydroxy-isoflavone are obtained, 7-ethoxy-isoflavone content: 0.1% by weight, yield: 90.5%.

Quelle