Reaktion #6373

Reaktionsgleichung

2,4-dihydroxy-phenyl-benzyl-ketone

morpholine

ethyl-orthoformate

→

7-hydroxy-isoflavone

Ausbeute 91.9%

Lösungsmittel

dimethyl-formamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter 25 minutes crystallization
2. 2
   workup.ADDITIONAt the end of the reaction time the crystallized suspension is diluted with 120 ml of chloroform and it
3. 3
   Sonstigeis crystallized at 0° C. for 2 hours
4. 4
   FiltrationAfter filtration the product
5. 5
   Sonstigedried

Vorschrift

50 g (0.219 mole) of a mixture of 2,4-dihydroxy-phenyl-benzyl-ketone, 20 ml of dimethyl-formamide, 2.6 ml of morpholine and 39.06 g (0.26 mole) of ethyl-orthoformate is stirred for 7 hours at 80°-90° C. After 25 minutes crystallization can be observed. At the end of the reaction time the crystallized suspension is diluted with 120 ml of chloroform and it is crystallized at 0° C. for 2 hours. After filtration the product is covered twice with 45 ml of chloroform and dried. 47.9 g of 7-hydroxy-isoflavone are obtained.

Quelle