Reaktion #63725

Reaktionsgleichung

sodium bicarbonate

2,3-dimethylpyridine 1-oxide

trichloroacetyl chloride

→

2-chloromethyl-3-methylpyridine

Lösungsmittel

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturat reflux
2. 2
   TemperaturThe reaction mixture is heated
3. 3
   Temperaturunder reflux for 2.5 hours
4. 4
   Waschenthe resulting solution is washed several times with methylene chloride
5. 5
   TrocknenThe organic phase is dried with sodium sulphate
6. 6
   Filtrationfiltered
7. 7
   Einengenconcentrated
8. 8
   SonstigeThe residue is chromatographed on silica gel with methylene chloride
9. 9
   Sonstigethe pressure being produced with nitrogen gas

Vorschrift

A solution of 15 g (0.12 mol) of 2,3-dimethylpyridine 1-oxide in 75 ml of chloroform is boiled at reflux and treated as rapidly as possible with 37 ml of trichloroacetyl chloride (it is advantageous to add the acid chloride through the reflux condenser). The reaction mixture is heated under reflux for 2.5 hours, subsequently poured into a mixture of ice and sodium bicarbonate and the resulting solution is washed several times with methylene chloride. The organic phase is dried with sodium sulphate, filtered and concentrated. The residue is chromatographed on silica gel with methylene chloride, the medium pressure flash chromatography method being used and the pressure being produced with nitrogen gas. The 2-chloromethyl-3-methylpyridine obtained is processed directly.

Quelle