Reaktion #63696

Reaktionsgleichung

3-aminophenol

acetic anhydride

→

3-hydroxyacetanilide

Ausbeute 89.3%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONAfter complete addition
2. 2
   Temperaturthe reaction mixture was heated on a steam bath for 10 minutes
3. 3
   SonstigeA precipitate formed
4. 4
   Filtrationwas collected by filtration
5. 5
   WaschenThe filter cake was washed with cold water
6. 6
   Sonstigedried in a desiccator for two hours

Vorschrift

To a stirred solution of 66.0 g (0.60 mole) of 3-aminophenol in 180 mL of water was added dropwise 77.9 g (0.76 mole) of acetic anhydride. After complete addition, the reaction mixture was heated on a steam bath for 10 minutes, then cooled to 0° C. A precipitate formed and was collected by filtration. The filter cake was washed with cold water and dried in a desiccator for two hours to yield 81.0 g of 3-hydroxyacetanilide (mp 144°-146° C.).

Quelle