Reaktion #63678

Reaktionsgleichung

2-aminomethyl-4-(1,1-dimethylethyl)-phenol hydrochloride

pyridine

acetyl chloride

→

2-Acetamidomethyl-4-(1,1-dimethylethyl)-phenol

Lösungsmittel

1,4-dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooling with ice
2. 2
   workup.STIRRINGThe mixture is then stirred for 2.5 hours at 90°
3. 3
   Sonstigethe precipitate which has crystallized out
4. 4
   Filtrationis filtered off with suction

Vorschrift

43 g (0.2 mole) of 2-aminomethyl-4-(1,1-dimethylethyl)-phenol hydrochloride are suspended in 400 ml of 1,4-dioxane, and 40 ml of pyridine are added. 40 ml (0.55 mole) of acetyl chloride are added dropwise while stirring and cooling with ice. The mixture is then stirred for 2.5 hours at 90° and poured into ice water, and the precipitate which has crystallized out is filtered off with suction.

Quelle