Reaktion #636526

Reaktionsgleichung

diisopropylethylamine

N-Benzyl-2-bromomethylpiperidine

5-(4-fluoro-phenyl)-2H-tetrazole

potassium carbonate

→

(RS)-1-Benzyl-2-[5-(4-fluoro-phenyl)-tetrazol-2-ylmethyl]-piperidine

Lösungsmittel

xylene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationfiltered
2. 2
   Sonstigesolvent removed at reduced pressure
3. 3
   Sonstigethe residue column chromatographed (silica gel; diethyl ether/petroleum ether 40:60 eluant)
4. 4
   Sonstigeto give
5. 5
   Sonstigeremoving solvent at reduced pressure the title compound 10.44 g

Vorschrift

N-Benzyl-2-bromomethylpiperidine (2.1 g), 5-(4-fluoro-phenyl)-2H-tetrazole (1.28 g) and potassium carbonate (6 g) were combined in xylene (100 ml) containing diisopropylethylamine (7 ml) and boiled for 16 h. The reaction mixture was cooled to room temperature, filtered, solvent removed at reduced pressure and the residue column chromatographed (silica gel; diethyl ether/petroleum ether 40:60 eluant) to give after combining appropriate fractions and removing solvent at reduced pressure the title compound 10.44 g.

Quelle