Reaktion #63584

Reaktionsgleichung

aluminium chloride

fluorobenzene

hydrochloric acid

4-fluorobenzeneacetonitrile

bromine

→

4-fluoro-α-(4-fluorophenyl)benzeneacetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe resulting reaction mixture
2. 2
   workup.STIRRINGAfter stirring for 30 minutes at 50° C.
3. 3
   ExtraktionThe product was extracted with methylbenzene
4. 4
   SonstigeThe extract was dried
5. 5
   Sonstigeevaporated
6. 6
   SonstigeThe residue was crystallized twice from 2-propanol

Vorschrift

70 Parts of 4-fluorobenzeneacetonitrile were heated at 120° C. and there were added dropwise 83 parts of bromine and stirring was continued for 30 minutes. The resulting reaction mixture was added dropwise to a stirred mixture (room temperature) of 85 parts of aluminium chloride and 200 parts of fluorobenzene (exothermic reaction: temperature rises to 50° C.). After stirring for 30 minutes at 50° C., the reaction mixture was poured onto a mixture of crushed ice and 75 parts of hydrochloric acid solution. The product was extracted with methylbenzene. The extract was dried and evaporated. The residue was crystallized twice from 2-propanol, yielding 51 parts of 4-fluoro-α-(4-fluorophenyl)benzeneacetonitrile, mp. 63.5° C. (intermediate 13).

Quelle