Reaktion #63526

Reaktionsgleichung

N-Ethyl-cyclohexylamine

chloroacetyl chloride

triethylamine

→

N-ethyl-N-cyclohexyl-chloroacetamide

Ausbeute 72.1%

Lösungsmittel

benzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooling
2. 2
   workup.ADDITIONThe reaction mixture is poured onto ice-water
3. 3
   Extraktionextracted with ether
4. 4
   WaschenThe ether layer is washed with an aqueous sodium hydrogen carbonate solution
5. 5
   Trocknenan aqueous saturated sodium chloride solution and dried over anhydrous magnesium sulfate
6. 6
   workup.DISTILLATIONAfter distilling off the solvent
7. 7
   workup.DISTILLATIONthe resulting residue is distilled under reduced pressure

Vorschrift

N-Ethyl-cyclohexylamine (2.6 g) is dissolved in dry benzene (20 ml). To the solution are added dropwise with stirring chloroacetyl chloride (2.6 g) and triethylamine (2.4 g) under ice-cooling. The mixture is stirred under ice-cooling for one hour and further at room temperature for one hour. The reaction mixture is poured onto ice-water and extracted with ether. The ether layer is washed with an aqueous sodium hydrogen carbonate solution and an aqueous saturated sodium chloride solution and dried over anhydrous magnesium sulfate. After distilling off the solvent, the resulting residue is distilled under reduced pressure to give N-ethyl-N-cyclohexyl-chloroacetamide (3 g), b.p. 118°-120° C./0.2 mmHg.

Quelle