Reaktion #63520

ord-25ebba0f0ad9463a8279cd0133e1a0db

Reaktionsgleichung

COc1cc2c(cc1OC)CNCC2
1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline
CC(=O)Oc1ccc(CC(=O)Cl)cc1
4-acetoxyphenylacetyl chloride
→
COc1cc2c(cc1OC)CN(C(=O)Cc1ccc(OC(C)=O)cc1)CC2
N-(4-acetoxyphenylacetyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline

Edukte

COc1cc2c(cc1OC)CNCC2
1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline
CC(=O)Oc1ccc(CC(=O)Cl)cc1
4-acetoxyphenylacetyl chloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Using the procedure described in Example 12, 15.0 g of 1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline was reacted with 4-acetoxyphenylacetyl chloride to give 13.0 g of N-(4-acetoxyphenylacetyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04766131uspto-grants-1988_08