Reaktion #635131

Reaktionsgleichung

2-Bromo-3-nitroanisole

2-bromo-3-nitroanisole

Na2CO3

→

2-bromo-3 methoxyaniline

Ausbeute 91.0%

Lösungsmittel

ethanol

water

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturat reflux for 3.5 h
2. 2
   Extraktionthe product extracted with CH2Cl2 (3×50 mL)
3. 3
   TrocknenThe extracts were dried (Na2SO4)
4. 4
   Filtrationfiltered
5. 5
   Einengenconcentrated in vacuo

Vorschrift

2-Bromo-3-nitroanisole B3 (1.00 g; 4.31 mmol) was dissolved in glacial acetic acid (11.0 mL) and ethanol (11.0 mL). To this solution was added iron powder (0.98 g; 17.5 mmol). The mixture was stirred at reflux for 3.5 h and worked up. The reaction mixture was diluted with water (35 mL), neutralized with solid Na2CO3 and the product extracted with CH2Cl2 (3×50 mL). The extracts were dried (Na2SO4), filtered and concentrated in vacuo to afford the crude product, 2-bromo-3 methoxyaniline B4 (91%; 0.79 g) as a pale yellow oil.

Quelle