Reaktion #63472

Reaktionsgleichung

2-(3-pyridylmethyl)-6-(2-methyl-1,3-dioxolan-2-yl)naphthalene

sodium carbonate

→

2-(3-pyridylmethyl)-6-acetylnaphthalene

Ausbeute 101.3%

Lösungsmittel

hydrochloric acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with methylene chloride
2. 2
   TrocknenThe organic layer was dried over sodium sulfate
3. 3
   Sonstigethe solvent removed under reduced pressure

Vorschrift

A solution of 150 mg of 2-(3-pyridylmethyl)-6-(2-methyl-1,3-dioxolan-2-yl)naphthalene in 15 ml of 1N hydrochloric acid was allowed to stand for 3 hours at room temperature. The solution was neutralized with sodium carbonate and extracted with methylene chloride. The organic layer was dried over sodium sulfate and the solvent removed under reduced pressure to give 130 mg of 2-(3-pyridylmethyl)-6-acetylnaphthalene as an oil.

Quelle