Reaktion #63471

Reaktionsgleichung

2-(3-pyridylcarbonyl)-6-(2-methyl-1,3-dioxolan-2-yl)naphthalene

triethylene glycol

hydrazine

potassium hydroxide

→

2-(3-pyridylmethyl)-6-(2-methyl-1,3dioxolan-2-yl)naphthalene

Ausbeute 62.0%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe temperature was then raised to 210° C. for 1 hour
2. 2
   TemperaturThe mixture was cooled
3. 3
   Extraktionextracted with methylene chloride
4. 4
   TrocknenThe organic layer was dried over sodium sulfate
5. 5
   Sonstigethe solvent removed under reduced pressure
6. 6
   Sonstigethe residue chromatographed on silica gel

Vorschrift

A mixture of 270 mg of 2-(3-pyridylcarbonyl)-6-(2-methyl-1,3-dioxolan-2-yl)naphthalene, 7 ml of triethylene glycol, 1 ml of anhydrous hydrazine and 500 mg of potassium hydroxide were heated at 160° C. for 30 minutes. The temperature was then raised to 210° C. for 1 hour. The mixture was cooled, poured into water and extracted with methylene chloride. The organic layer was dried over sodium sulfate, the solvent removed under reduced pressure and the residue chromatographed on silica gel to give 160 mg of 2-(3-pyridylmethyl)-6-(2-methyl-1,3dioxolan-2-yl)naphthalene as an oil.

Quelle