Reaktion #634624

ord-9c17e25ad79b4c688b20df8d1503cead

Reaktionsgleichung

Cc1ccncn1
4-methylpyrimidine
COC(OC)N(C)C
N,N-dimethylformamide dimethylacetal
→
CN(C)/C=C/c1ccncn1
title compound
Ausbeute 95.1%
CN(C)/C=C/c1ccncn1
dimethyl-[(E)-2-(4-pyrimidinyl)vinyl]amine
Ausbeute 95.1%

Edukte

Cc1ccncn1
4-methylpyrimidine
COC(OC)N(C)C
N,N-dimethylformamide dimethylacetal

Reagenzien

Keine

Lösungsmittel

CN(C)C=O
DMF

Reaktionsbedingungen

Temperatur
140°CELSIUS
Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    TemperaturThe reaction solution was cooled
  2. 2
    workup.DISTILLATIONthe solvent was distilled off under reduced pressure

Vorschrift

A mixture of 10 g of 4-methylpyrimidine, 38 g of N,N-dimethylformamide dimethylacetal (DMFDMA) and 46.6 g of DMF was stirred in a sealed tube at 140° C. for 24 hours. The reaction solution was cooled and the solvent was distilled off under reduced pressure to provide 15.08 g (yield: 95%) of the title compound as brown crystal.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07939536B2uspto-grants-2011_05