Reaktion #63451

Reaktionsgleichung

cyanogen bromide

6,7-dihydro-5H-dibenz[c,e]azepine

→

5,7-dihydro-6H-dibenz[c,e]azepine-6-carbonitrile

Lösungsmittel

chloroform

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationa small amount of the hydrobromide salt of the still unreacted azepine is filtered off
2. 2
   WaschenThe filtrate is washed three times with water
3. 3
   Trocknendried over anhydrous sodium sulphate
4. 4
   Sonstigeevaporated

Vorschrift

A solution of 1.91 g of cyanogen bromide in 20 ml of chloroform is added dropwise at 5°-10° C. within 25 minutes to a solution, cooled to 5° C., of 7 g of 6,7-dihydro-5H-dibenz[c,e]azepine in 50 ml of chloroform. The reaction mixture is stirred for a further 1 hour and then a small amount of the hydrobromide salt of the still unreacted azepine is filtered off. The filtrate is washed three times with water, dried over anhydrous sodium sulphate and evaporated. There is obtained solid 5,7-dihydro-6H-dibenz[c,e]azepine-6-carbonitrile, m.p. 123°-126° C.

Quelle