Reaktion #63423

Reaktionsgleichung

diethyl malonate

magnesium diethyl malonate

2-[-4'-(4"-cyano-phenoxy)-phenoxy]-propionyl chloride

→

desired compound

Ausbeute 72.0%

diethyl-2-[4'-(4"-cyano-phenoxy)-phenoxy]-propionyl-malonate

Ausbeute 72.0%

Lösungsmittel

ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturis heated
2. 2
   workup.WAITto boiling for an hour

Vorschrift

A mixture of 30 g of 2-[-4'-(4"-cyano-phenoxy)-phenoxy]-propionyl chloride and 30 ml of ether is added dropwise to a 35% etheral solution of magnesium diethyl malonate prepared from 17.6 g of diethyl malonate. The addition of the acid chloride having been completed the reaction mixture is heated to boiling for an hour and worked up as described in Example 1. Thus 30 g of the desired compound are obtained in the form of a viscous oil which solidifies on standing and melts at 42°-46° C. Yield 72%.

Quelle