Reaktion #634119

Reaktionsgleichung

sodium hydroxide

(4′-{1-ethyl-1-[3-methyl-4-((E)-4,4,4-trifluoro-3-hydroxy-3-trifluoromethyl-1-butenyl)-phenyl]-propyl}-3-fluoro-2′-methyl-biphenyl-4-yl)acetic acid methyl ester

→

compound

Ausbeute 95.0%

(4′-{1-ethyl-1-[3-methyl-4-((E)-4,4,4-trifluoro-3-hydroxy-3-trifluoromethyl-1-butenyl)-phenyl]-propyl}-3-fluoro-2′-methyl-biphenyl-4-yl)-acetic Acid

Ausbeute 95.0%

Lösungsmittel

methanol tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThen, the reaction mixture was concentrated under reduced pressure
2. 2
   SonstigeThe resulting residue was purified by silica gel chromatography (chloroform:methanol=8:3, saturated with water)

Vorschrift

A 1 N sodium hydroxide aqueous solution (0.145 mL, 0.145 mmol) was added to a solution of (4′-{1-ethyl-1-[3-methyl-4-((E)-4,4,4-trifluoro-3-hydroxy-3-trifluoromethyl-1-butenyl)-phenyl]-propyl}-3-fluoro-2′-methyl-biphenyl-4-yl)acetic acid methyl ester (Example 72-(1); 29.6 mg, 0.049 mmol) in methanol-tetrahydrofuran (1:1, 1 mL), and the mixture was stirred at 60° C. for one hour. Then, the reaction mixture was concentrated under reduced pressure. The resulting residue was purified by silica gel chromatography (chloroform:methanol=8:3, saturated with water) to give the target compound as a colorless oil (27.5 mg, 95%).

Quelle