Reaktion #633929

Reaktionsgleichung

sodium bicarbonate

4-Chloroaniline

lithium tetrafluoroborate

oxetane

→

title compound

Ausbeute 67.9%

3-(4-chlorophenylamino)propan-1-ol

Ausbeute 67.9%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionfollowed by extraction with chloroform
2. 2
   ExtraktionThe resulting extract
3. 3
   Trocknenwas dried over magnesium sulfate
4. 4
   Einengenconcentrated under reduced pressure
5. 5
   SonstigeThe residue was purified by silica gel column chromatography (elution solvent: heptane-ethyl acetate system)

Vorschrift

4-Chloroaniline (4.39 g) and lithium tetrafluoroborate (3.32 g) were added to a solution of oxetane (1.00 g) in acetonitrile (20 mL) at room temperature, and the reaction solution was stirred at room temperature for 52 hours. A saturated sodium bicarbonate solution was added to the reaction solution, followed by extraction with chloroform. The resulting extract was dried over magnesium sulfate and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (elution solvent: heptane-ethyl acetate system) to obtain 2.17 g of the title compound. The property values of the compound are as follows.

Quelle