Reaktion #63359

ord-c89bd57820c74b11848e1d5d2d04ae3e

Reaktionsgleichung

CCCN1C(=O)C2(CC)CC(c3ccc([N+](=O)[O-])cc3)(C2)C1=O
5-ethyl-1-(4-nitrophenyl)-3-n-propyl-3-azabicyclo[3.1.1]-heptane-2,4-dione
CCOCC
ether
→
CCCN1C(=O)C2(CC)CC(c3ccc(N)cc3)(C2)C1=O
1-(4-aminophenyl)-5-ethyl-3-n-propyl-3-azabicyclo[3.1.1]heptane-2.4-dione

Edukte

CCCN1C(=O)C2(CC)CC(c3ccc([N+](=O)[O-])cc3)(C2)C1=O
5-ethyl-1-(4-nitrophenyl)-3-n-propyl-3-azabicyclo[3.1.1]-heptane-2,4-dione
CCOCC
ether

Reagenzien

[Pd]
palladium-on-carbon

Lösungsmittel

CCOC(C)=O
ethyl acetate

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

In a manner analogous to that described in Example 12a, 6.3 g of 5-ethyl-1-(4-nitrophenyl)-3-n-propyl-3-azabicyclo[3.1.1]-heptane-2,4-dione are dissolved in 120 ml of ethyl acetate, hydrogenated in the presence of 0.6 g of 5% palladium-on-carbon and worked up. Melting point 124.5°-125° (from ether).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04764640uspto-grants-1988_08