Reaktion #633160

Reaktionsgleichung

ester

6-[(2-Benzylsulfanylbenzyl)ethylamino]nicotinic acid methyl ester

KOH

→

6-[(2-Benzylsulfanylbenzyl)ethylamino]nicotinic acid

Lösungsmittel

THF

H2O

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenconcentrated
2. 2
   Sonstigeto remove THF
3. 3
   WaschenThe aqueous phase was washed with ethyl ether
4. 4
   ExtraktionThe acidified solution was extracted with Et2O or EtOAc (3×)
5. 5
   Trocknendried over MgSO4
6. 6
   Filtrationfiltered
7. 7
   Einengenconcentrated in vacuo
8. 8
   Sonstigeto give a white solid

Vorschrift

To a solution of the ester of Example 6 in THF (0.8 mL) was added a solution of KOH (14 mg, 0.255 mmol) in H2O (0.2 mL). The mixture was stirred at 50° C., then concentrated to remove THF. The aqueous phase was washed with ethyl ether, then the aqueous phase was acidified until pH 3-4 was reached. The acidified solution was extracted with Et2O or EtOAc (3×), dried over MgSO4, filtered and concentrated in vacuo to give a white solid.

Quelle