Reaktion #6330

Reaktionsgleichung

Acetic anhydride

(±) N-[(9,9a-dihydro-3-oxo-1H,3H-oxazolo[3,4-a]indol-1-yl)methyl]acetamide

methanesulfonic anhydride

→

title compound

N-[(7-Acetyl-9,9a-dihydro-3-oxo-1H,3H-oxazolo-[3,4-a]indol-1-yl)methyl]acetamide

Lösungsmittel

methylene chloride

methane sulfonic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto warm slowly to 20°-25° overnight
2. 2
   workup.ADDITIONThen the mixture is added
3. 3
   Extraktionis extracted with ethyl acetate (4×3 ml)
4. 4
   WaschenThe combined organic layers are washed with saturated aqueous sodium bicarbonate (2 ml), saline (1 ml)
5. 5
   Trocknendried over anhydrous potassium carbonate
6. 6
   Einengenconcentrated to an oil
7. 7
   ExtraktionExtraction of the appropriate band and concentration

Vorschrift

Acetic anhydride (53 μl) is slowly added to a mixture of (±) N-[(9,9a-dihydro-3-oxo-1H,3H-oxazolo[3,4-a]indol-1-yl)methyl]acetamide (X diastereomer A, EXAMPLE 18, 21 mg), methanesulfonic anhydride (33 mg) in methylene chloride (0.1 ml) and methane sulfonic acid (0.50 ml) at 0°. The temperature is kept below 15° for 3 hr, then allowed to warm slowly to 20°-25° overnight. Then the mixture is added to crushed ice (0.5 ml). After the ice has melted the mixture is extracted with ethyl acetate (4×3 ml). The combined organic layers are washed with saturated aqueous sodium bicarbonate (2 ml), saline (1 ml), dried over anhydrous potassium carbonate and concentrated to an oil. The oil is place on a silica prepratory plate (14 cm×17.5 cm, 250μ) and developed in methanol/methylene chloride (5/95, 3×). Extraction of the appropriate band and concentration give the title compound.

Quelle