Reaktion #63252

Reaktionsgleichung

2-pentyl-3,4-dichlorophenol

2,3-dihydro-2-hydroxy-4,5-dichlorobenzofuran

propyltriphenylphosphonium bromide

phenol

6-bromohexanoic acid

2-(2-pentenyl)-3,4-dichlorophenol

→

desired title product

6-(2-Pentyl-3,4-dichlorophenoxy)hexanoic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto provide 840 mg
2. 2
   Sonstigeprovided 300 mg
3. 3
   Sonstigeto provide 58 mg

Vorschrift

Following the general procedure of Example 6B, 2.3 g. of 2,3-dihydro-2-hydroxy-4,5-dichlorobenzofuran and 17.3 g. of propyltriphenylphosphonium bromide were reacted to provide 840 mg. of 2-(2-pentenyl)-3,4-dichlorophenol which upon hydrogenation following the procedure of Example 6C provided 300 mg. of 2-pentyl-3,4-dichlorophenol. This phenol was then reacted with 5.1 mmoles of 6-bromohexanoic acid following the procedure of Example 1C to provide 58 mg. of the desired title product. NMR.

Quelle