Reaktion #63235

ord-1847d07e81a74fdd8f8adb629f105173

Reaktionsgleichung

CCCN1C[C@@H](NC(=O)OCc2ccccc2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21
6-n-propylergoline
CCCN1C[C@@H](NC(=O)OCc2ccccc2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21
8α-benzyloxycarbonylamino-6-n-propylergoline
[H][H]
hydrogen
→
CCCN1C[C@@H](N)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21
8α-amino-6-n-propylergoline

Edukte

CCCN1C[C@@H](NC(=O)OCc2ccccc2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21
6-n-propylergoline
CCCN1C[C@@H](NC(=O)OCc2ccccc2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21
8α-benzyloxycarbonylamino-6-n-propylergoline
[H][H]
hydrogen

Reagenzien

[Pd]
palladium on charcoal

Lösungsmittel

CCO
ethanol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    FiltrationThe mixture is filtered
  2. 2
    Einengenconcentrated
  3. 3
    Sonstigeis crystallised from methanol

Vorschrift

12 g (ca 30 mM) of 8α-benzyloxycarbonylamino)-6-n-propylergoline obtained from step (d) and 1.5 g palladium on charcoal (10% by weight) in 500 ml ethanol are hydrogenated at normal pressure until hydrogen uptake ceases. The mixture is filtered and concentrated. This resultant heading compound is crystallised from methanol.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04764517uspto-grants-1988_08