Reaktion #63227

Reaktionsgleichung

pyridine-2-carboxylic acid

thionyl chloride

→

picolinic acid chloride

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe suspension was heated
2. 2
   SonstigeThereafter, the mixture was evaporated to dryness under reduced pressure
3. 3
   workup.ADDITIONthe residue was treated with toluene
4. 4
   Sonstigeagain evaporated to dryness

Vorschrift

10.0% of pyridine-2-carboxylic acid were suspended in 150 ml of toluene and the suspension was heated to reflux for 2 hours with 17.7 ml of thionyl chloride and 3 drops of dimethylformamide. Thereafter, the mixture was evaporated to dryness under reduced pressure, the residue was treated with toluene and again evaporated to dryness. There was obtained picolinic acid chloride as dark green crystals which were used directly in the next step.

Quelle