Reaktion #63226

Reaktionsgleichung

t-butyl [2-(5-methylthiophene-2-carboxamido)ethyl]carbamate

trifluoroacetic acid

hydrochloride

→

N-(2-aminoethyl)-5-methylthiophene-2-carboxamide hydrochloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas recrystallized from ethanol/ether

Vorschrift

14.9 g of t-butyl [2-(5-methylthiophene-2-carboxamido)ethyl]carbamate were reacted with trifluoroacetic acid in an analogous manner to that described in Example 2, paragraph 2. The residue was converted into the hydrochloride which was recrystallized from ethanol/ether, whereby there was obtained N-(2-aminoethyl)-5-methylthiophene-2-carboxamide hydrochloride as light beige crystals, m.p. 161°-162°.

Quelle