Reaktion #632027

Reaktionsgleichung

3-quinuclidinone

benzaldehyde

sodium hydroxide

→

(Z)-2-benzylidenequinuclidin-3-one

Ausbeute 91.2%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas refluxed for 1.5 h
2. 2
   TemperaturAfter the solution was cooled
3. 3
   Sonstigethe yellow precipitates
4. 4
   Sonstigewere collected
5. 5
   Waschenwashed with ethanol
6. 6
   Sonstigedried

Vorschrift

A mixture of 3-quinuclidinone (20.9 g, 167 mmol), benzaldehyde (17.7 g, 167 mmol), and one pellet of sodium hydroxide in 75 mL of ethanol was refluxed for 1.5 h. After the solution was cooled, the yellow precipitates were collected, washed with ethanol, and dried to give (Z)-2-benzylidenequinuclidin-3-one (32.5 g, yield: 91.2%, mp 130-132° C.).

Quelle