Reaktion #631973

Reaktionsgleichung

acetone

6-methylisocytosine

carbonyldiimidazole

→

desired product

N-(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)-1H-imidazole-1-carboxamide

Lösungsmittel

dimethylsulfoxide

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was cooled to about room temperature

Vorschrift

A mixture of 6-methylisocytosine (1 eq.) and carbonyldiimidazole (1.5 eq.) were combined in dimethylsulfoxide (DMSO) and the solution was stirred at 60° C. for 2 hours. The mixture was cooled to about room temperature and acetone added after which the desired product precipitated as a white powder that was collected by filtration. The procedure of A. T. Cate, P. Y. W. Dankers, H. Kooijman, A. L. Spek, R. P. Sijbesma, and E. W. Meijer, J. of Am. Chem. Soc., 2003, 125, 6860 was followed for this step. The product can be used without further purification.

Quelle