Reaktion #631972

Reaktionsgleichung

hydroquinone

3-Chloro-3-oxopropyl acrylate

2-aminopyridine

triethylamine

→

3-oxo-3-(pyridin-2-ylamino)propyl acrylate

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent is removed under reduced pressure
2. 2
   Sonstigethe crude material purified over silica

Vorschrift

3-Chloro-3-oxopropyl acrylate, 1, (1 eq.), 2-aminopyridine (1 eq.) and triethylamine (3 eq.) are dissolved in toluene at 0° C. A few crystals of hydroquinone is added to inhibit any polymerization side reactions. The solution is allowed to stir approximately 18 hours at a temperature from about 0° C. to room temperature. The solvent is removed under reduced pressure and the crude material purified over silica. For a more detailed account of this procedure See M. A. Diab, A. Z. El-Sonbati, A. A. El-S anabori, F. I. Taha, Polymer Degrad. Stab. 1989, 24, 51, included herein by reference.

Quelle