Reaktion #63196

Reaktionsgleichung

3-[4-(5-bromo-3-methylpyrid-2-yl)butyl]-6-(pyrid-3-ylmethyl)-3H-1,2,3-triazolo[5,4-b]-pyridine

ammonium hydroxide

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title compound

2-[4-(5-Bromo-3-methylpyrid-2-yl)butylamino]-3-hydroxy-5-(pyrid-3-ylmethyl)pyridine

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   Sonstigeto give a solution of ca. pH 8
3. 3
   Extraktionextracted with chloroform (4×30 ml)
4. 4
   TrocknenThe combined chloroform extracts were dried over magnesium sulphate
5. 5
   Einengenconcentrated in vacuo
6. 6
   Sonstigethe residue was chromatographed on silica
7. 7
   Wascheneluted with 7.5% v/v methanol in chloroform
8. 8
   Sonstigecrystallised under ether

Vorschrift

A mixture of 3-[4-(5-bromo-3-methylpyrid-2-yl)butyl]-6-(pyrid-3-ylmethyl)-3H-1,2,3-triazolo[5,4-b]-pyridine (0.6 g) and polyphosphoric acid (ca. 6 g) was heated with stirring at 190°-200° C. for 40 minutes. The cooled residue was dissolved in aqueous ammonium hydroxide to give a solution of ca. pH 8 and extracted with chloroform (4×30 ml). The combined chloroform extracts were dried over magnesium sulphate, concentrated in vacuo and the residue was chromatographed on silica eluted with 7.5% v/v methanol in chloroform and then crystallised under ether to give the title compound (0.12 g), m.p. 164°-166° C.

Quelle