Reaktion #63144

Reaktionsgleichung

2-amino-4-methoxy-6-methylpyrimidine

1,2,4-triazole

formaldehyde

acetic acid

→

4-methoxy-6-methyl-2-(1,2,4-triazol-1-ylmethylamino)pyrimidine

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturis refluxed for 11/2 hours
2. 2
   SonstigeFirst a clear solution forms, from which the reaction product precipitates in crystalline form after a time
3. 3
   TemperaturAfter the reaction mixture has cooled
4. 4
   Filtrationthe crystalline title compound is filtered with suction
5. 5
   Sonstigedried

Vorschrift

With stirring, a mixture of 13.9 g (0.1 mole) of 2-amino-4-methoxy-6-methylpyrimidine, 7 g (0.1 mole) of 1,2,4-triazole, 9.4 g (0.11 mole) of aqueous 35% formaldehyde and 1 g of acetic acid in 100 ml of methanol is refluxed for 11/2 hours. First a clear solution forms, from which the reaction product precipitates in crystalline form after a time. After the reaction mixture has cooled, the crystalline title compound is filtered with suction and dried. Yield: 14 g. Melting point: 191°-193° C.

Quelle