Reaktion #631439

Reaktionsgleichung

1-benzyl-2-piperidine methanol

diketene

→

acetoacetic acid-N-benzyl-2-piperidinylmethyl ester

Ausbeute 70.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe reaction product was purified by silica gel column chromatography (eluent:chloroform:methanol=9:1 v/v)

Vorschrift

Then, 10.0 g of the 1-benzyl-2-piperidine methanol and 4.30 g of diketene were reacted similarly as in Reference Example 1, and the reaction product was purified by silica gel column chromatography (eluent:chloroform:methanol=9:1 v/v), to obtain 9.86 g of acetoacetic acid-N-benzyl-2-piperidinylmethyl ester (yield: 69.9%). This was used in the reaction of Example 5 without distillation.

Quelle