Reaktion #631438

Reaktionsgleichung

2-piperidine methanol

benzyl chloride

triethylamine

→

1-benzyl-2-piperidine methanol

Ausbeute 52.9%

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturat reflux for 4 hours
2. 2
   FiltrationThe reaction mixture was filtered
3. 3
   Einengenthe filtrate was concentrated
4. 4
   workup.DISTILLATIONthe concentrate was distilled under reduced pressure

Vorschrift

A mixture of 12.9 g of 2-piperidine methanol, 13.2 g of benzyl chloride, 10.5 g of triethylamine and 50 ml of toluene was stirred at reflux for 4 hours. The reaction mixture was filtered, the filtrate was concentrated, and the concentrate was distilled under reduced pressure to obtain 11.3 g of 1-benzyl-2-piperidine methanol (yield: 52.9%). b.p.: 107° C./2 mmHg

Quelle