Reaktion #63127

Reaktionsgleichung

hexanoic acid, 3-tetradecylphenyl ester

aluminum chloride

hydrochloric acid

→

desired compound

1-(2-Hydroxy-4-tetradecylphenyl)-1-hexanone

Lösungsmittel

ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturHeating
2. 2
   workup.WAITwas continued for an additional hour
3. 3
   Temperaturto cool
4. 4
   WaschenThe ether layer was washed with water
5. 5
   Sonstigedried
6. 6
   Sonstigethe solvent removed

Vorschrift

A 14.28 g portion of hexanoic acid, 3-tetradecylphenyl ester was heated to 90°-100° C., then 9.81 g of aluminum chloride was added in portions over 2 hours. Heating was continued for an additional hour, then the mixture was allowed to cool, diluted with ether and poured onto a mixture of ice and concentrated hydrochloric acid. The ether layer was washed with water, then dried and the solvent removed, giving 7 g of the desired compound, mp 44°-45° C.

Quelle