Reaktion #63107

Reaktionsgleichung

2-[2-(2,2,2-trifluoroethyl)guanidino]-4-[4-(3-cyano-2-methylisothioureido)butyl]thiazole

N-methylhydrazine

maleate

→

3-amino-1-methyl-5-[4-(2-[2-(2,2,2-trifluoroethyl)guanidino]thiazol-4-yl)butylamino]-1H-1,2,4-triazole dimaleate

Lösungsmittel

dimethylformamide

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated at 40°-45° for 40 hours
2. 2
   SonstigeThe solvent was removed
3. 3
   SonstigeThe oil obtained

Vorschrift

A mixture of 2-[2-(2,2,2-trifluoroethyl)guanidino]-4-[4-(3-cyano-2-methylisothioureido)butyl]thiazole (0.23 g.) and N-methylhydrazine (0.6 g.) in dimethylformamide (15 ml.) was heated at 40°-45° for 40 hours. The solvent was removed and the residue applied to 2 t.l.c. plates which were developed with chloroform/methanol/ammonia 9:1:0.1 v/v/v. The oil obtained was converted to a maleate in acetone to give 3-amino-1-methyl-5-[4-(2-[2-(2,2,2-trifluoroethyl)guanidino]thiazol-4-yl)butylamino]-1H-1,2,4-triazole dimaleate (56.8 mg.), m.p. 181°-183°.

Quelle