Reaktion #63075

Reaktionsgleichung

2-thiocytosine

N-(2-bromoethyl)phthalimide

1,8-diazabicyclo[5,4,0]undec-5-ene

→

4-amino-2-(2-phthalimidoethylthio)pyrimidine

Lösungsmittel

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeevaporated to dryness
2. 2
   workup.STIRRINGThe residue was stirred with a mixture of water and ethyl acetate
3. 3
   Sonstigethe insoluble material collected

Vorschrift

A mixture of 2-thiocytosine (0.51 g.), dimethylformamide (5 ml.), N-(2-bromoethyl)phthalimide (1.12 g.) and 1,8-diazabicyclo[5,4,0]undec-5-ene (0.67 g.) was stirred at room temperature for 6 hours and then evaporated to dryness. The residue was stirred with a mixture of water and ethyl acetate and the insoluble material collected to give 4-amino-2-(2-phthalimidoethylthio)pyrimidine which was used without further purification.

Quelle