Reaktion #630198

Reaktionsgleichung

(9-carboxynonyl)triphenylphosphonium bromide

8-bromo-N-methyloctanamide

triphenylphosphine

9-(3-benzyloxy-17β-hydroxyoestra-1,3,5(10)trien-7α-yl)-N-methylnon-8-enamide

→

9-(3,17β-dihydroxyoestra-1,3,5(10)-trien-7α-yl)-N-methyl-nonanamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethus obtained

Vorschrift

The procedure described in the last paragraph of Example 6 was repeated except that (7-N-methylcarbamoylheptyl)triphenylphosphonium bromide (prepared from 8-bromo-N-methyloctanamide and triphenylphosphine by a similar process to that described in the last part of Example 22) was used in place of (9-carboxynonyl)triphenylphosphonium bromide. The hydrogenation process described in the second paragraph of Example 6 was then repeated using the 9-(3-benzyloxy-17β-hydroxyoestra-1,3,5(10)trien-7α-yl)-N-methylnon-8-enamide thus obtained as starting material, and there was thus obtained as an oil 9-(3,17β-dihydroxyoestra-1,3,5(10)-trien-7α-yl)-N-methyl-nonanamide, the structure of which was confirmed by proton magnetic resonance and mass spectroscopy.

Quelle