Reaktion #62983

Reaktionsgleichung

4-Trifluoromethylphenylisocyanate

amine

4-[α-(2,4-ditert.-pentylphenoxy)-butyroyl]-6-hydroxy-7-amino-1,4-benzoxazine-3-one

→

( h )

4-[α-(2,4-ditert.-pentylphenoxy)-butyroyl]-6-hydroxy-7-(4-trifluoromethylphenylureido)-1,4-benzoxazine-3-one

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe solution was evaporated to dryness
2. 2
   Sonstigethe residue crystallized from toluene

Vorschrift

4-Trifluoromethylphenylisocyanate (2.55 g, 0.0136 mole) was added to the amine ((g), 6.56 g, 0.0136 mole) in THF (ml 100). After 1 hour stirring, the solution was evaporated to dryness and the residue crystallized from toluene to give the coupler ((h), 6 g, 67%) as white prisms. The product structure was confirmed by NMR analysis.

Quelle