Reaktion #62981

Reaktionsgleichung

Bromoacetic acid

amine

2-amino-4-benzyloxyphenol

→

bromoamide

2-α-bromoacetamido-4-benzyloxyphenol

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationAfter 1 hour the reaction mixture was filtered
2. 2
   Sonstigethe liquid evaporated to dryness under vacuum
3. 3
   SonstigeThe residue was crystallized from acetic acid (50 ml)

Vorschrift

Bromoacetic acid (13.9 g, 0.01 mole) and dicyclohexyldicarbodiimide (DCCD, 20.6 g, 0.01 mole) were added at room temperature under stirring to the amine ((b), 21.5 g, 0.01 mole) in THF (200 ml). After 1 hour the reaction mixture was filtered and the liquid evaporated to dryness under vacuum. The residue was crystallized from acetic acid (50 ml) to give the bromoamide ((c), 17 g, 50%) as white prisms. The product structure was confirmed by NMR analysis.

Quelle