Reaktion #62975

Reaktionsgleichung

water

2-(α-chloroacetamido)-hydroquinone

sodium methoxide

methanol

→

6-hydroxy-2H-1,4-benzoxazin-3-(4H)-one

Lösungsmittel

dimethylformamide

Reaktionsbedingungen

Vorschrift

30% sodium methoxide in methanol (18.4 g, 0.075 mole) was added under stirring to the 2-(α-chloroacetamido)-hydroquinone (13.4 g, 0.075 mole) in dimethylformamide (DMF 10 ml). The resulting solution was poured into water (150 ml) and the separated solid was Coupler (1) (9 g, 73%).

Quelle