Reaktion #62974

Reaktionsgleichung

α-chloroacetylchloride

2-aminohydroquinone

diethanolamine

hydrochloride

→

2-(α-chloroacetamido)-hydroquinone

Lösungsmittel

acetone

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with ethylacetate (500 ml)
2. 2
   SonstigeThe solvent was evaporated to dryness
3. 3
   Sonstigethe solid residue (4.20 g, 80%) was used without any further purification

Vorschrift

α-chloroacetylchloride (10.1 g, 0.128 mole) was added dropwise under stirring at room temperature to the 2-aminohydroquinone (4.16 g, 0.128 mole) in dry acetone (400 ml) and diethanolamine (2.04 ml, 0.128 mole). The reaction mixture was poured into water and hydrochloride acid (2,000 ml, pH 1), then extracted with ethylacetate (500 ml). The solvent was evaporated to dryness and the solid residue (4.20 g, 80%) was used without any further purification. The structure of the 2-(α-chloroacetamido)-hydroquinone was confirmed by NMR analysis.

Quelle